Yunzhi is a form of polypore mushroom used in Asian cultures to treat serious illness.† The† name Yunzhi is commonly used in Traditional Chinese Herbal Supplement (TCHS).† PSP stands for Polysaccharide Peptide, a protein-bound polysaccharide extracted from deep-layer-cultivated mycelia of the COV-1 strain of Yunzhi, also commonly known as Coriolus Versicolor or Turkey Tail.† The polysaccharide that are extracted from the fruit body (ie. the yunzhiís outer body) are of the lower efficacy versus the extraction from the mycelia, which can be more easily absorbed to the body.

Background on PSP

The following are highlights the background behind Wonder Herbís Essence of Yunzhi Polysaccharide Peptide (PSP) and its holistic benefits in combating mutation ailment.

Natural Yunzhi (Coriolus Versicolor)

Coriolus Versicolor

As such, the names of Yunzhi (as known in TCHS), Coriolus Versicolor, Trametes versicolor (also known scientifically as Polystictus versicolor), Kawaratake (as known in Japan)† and Turkey Tail (as known in North America) are the names commonly associated the same organic form of this organic mushroom product. While Polysaccharide Peptide (or PSP, as known in TCHS) and Polysaccharide Krestin (or PSK, as known in Japan) are names commonly associated with the extracted, concentrated form of this polypore mushroomís active ingredients, there are differences in their benefits.†

This polypore mushroom has shown immune enhancing, antimicrobial, antiviral and mutative cell inhibiting properties, which have been attributed to a protein-bound polysaccharide called Polysaccharide Peptide (PSP).  PSP is not only capable of stimulating the immune system but also modulating mutative cell function and the tissue environment to facilitate the local destruction of mutative cells by activated immune effector cells.†

PSP has a much higher potent efficacy over PSK due to the bounding of peptide to polysaccharide during the process of extraction and production.† Only when these two substances are bonded together, they can then be thoroughly absorbed by the human body and thus achieve the higher efficacy over other yunzhi production processes.† The common misunderstanding is that the higher percentage of polysaccharide would lead to higher benefits.† But, without the process of peptide bonded to polysaccharide, the polysaccharide is difficult to be absorbed within oneís body.†

More specifically, when polysaccharide are bonded to peptide, it can then connect with a type of material (ie. Ŗ1,3 and Ŗ1,6 polysaccharide receptor, called glucusan receptor) on the outer wall of human cells and can cause a curative biological response.† When PSP is taken orally, and under the guidance of peptide, it passes through the intestine to enter the body and connect with the lymphocyte macrophages, NK cells, T cells that have glucosan receptors and activates them.† This biological response enables the cells to secrete various disease-resistant materials like interferon, interleukins, prostaglandin, etc., along with other mutation resistant factors.†

When comparing different yunzhi products in the market, consumers should pay careful attention to compare its ingredients and choose a product with PSP.† Our Essence of Yunzhi is of the Polysaccharide Peptide (PSP) variety.† As well, since the mutative cell inhibiting ingredient of Yunzhi, protein bound polysaccharide, exists primarily in the mycelia, the strain Cov-1 used for our production of polysaccharide peptide (PSP) uses the deep layer cultivated mycelia as its raw material instead of using the crude fruit-body found in other brands.†

Since its discovery in 1971, over 350 scientific and clinical studies have been published demonstrating its potential benefits to a variety of diseases, especially mutation ailment.† In China and in Japan, PSP/PSK is currently used as mutative cell treatment, in conjunction with surgery, chemotherapy and/or radiation.

Some of benefits of this our TCHS, Essence of Yunzhi Polysaccharide Peptide (PSP) are:

  PSP is most effective when combined with a front-line clinical treatment regimen (chemotherapy, radiation therapy or surgery) for patients with many types of mutation ailments. Randomized controlled clinical trials and meta-analysis showed that overall survival and disease-free survival are improved in patients treated with adjuvant immunotherapy plus PSP. PSP is also beneficial for maintaining general immune health with no reported adverse side effects.

 It minimizes the toxic and side effects caused by chemotherapy and radiotherapy.† PSP can improve a patientís survival by restoring and enhancing cellular immune functions in patients with depressed immunity due to radiation and/or chemotherapy or surgical stress after curative resection of treatment.† As well, it has the ability to lower the cytotoxicity of certain clinical drugs via their interaction with cell cycle-dependent and apoptotic pathways.

 It alleviates common and undesirable symptoms suffered by clinical patients, such as fatigue, poor appetite, adverse pain, anxiety, insomnia, nausea, vomiting, and spontaneous night sweat.† Simply put, it improves the overall quality of life for its clinical patients.

 It stabilizes the white blood cell count (white blood cells combat infections, regulates the intensive and duration of immunal response and mediate cell-to-cell communication) ; increases the activity of NK and LAK cells, reverses the CD4+ /CD8+ ratio; and raises the value of Karnofsky evaluation.

 Other non-immunological properties includes improvement of appetite and liver function, calming of the central nervous system and enhancement of pain threshold. With the benefit of the immuno-therapeutic as well as the non-immunological properties present, PSP can be taken in a daily regimen as a preventative measure as well as oneís general health maintenance.


Because of the herbal nature of PSP, it reap all the natural curative properties but it does not suffer from any known side effects even when combined with conventional clinical medication. This is because PSP does not interact with other drugs nor affect hepatic drug-metabolizing enzyme activities indicating that drug efficacy is not affected by PSP when used with other medications.† Although its mutative cell inhibitor effect is not as potent as that of chemotherapeutic drugs, PSP does not cause harm to the normal cells. In other words, PSP possesses the ability of distinguishing between normal and abnormal growth cells.


PSP is recorded as a fungal extract suited for treatment regimens used in mutation ailment management by the American National Cancer Research Center but has not been evaluated by the Food and Drug Administration.


WARNING: However, because of the active immuno-modulating benefits of PSP, organ-transplant patients should use extreme care. Patients should consult your doctor before taken this product if you are currently on immune suppressant medication.

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